Kurt Zouma and Eden Hazard scored as Chelsea exploited the dismissals of Gabriel and Santi Cazorla to beat Arsenal 2-0 on Saturday and revive its Premier League title defence.
Gabriel was sent off late in the first half after a tussle with the provocative Diego Costa and Zouma, playing in place of Chelsea captain John Terry, put the host ahead in the 53rd minute.
Cazorla was shown a second yellow card for sliding in on Cesc Fabregas and Hazard made the game safe a minute from time with a shot that beat former Chelsea goalkeeper Petr Cech via a sizeable deflection off Calum Chambers.
It was Chelsea’s first home-league win of the campaign and, arriving on the back of Wednesday’s 4-0 win over Maccabi Tel Aviv in the Champions League.
Arsenal manager Arsene Wenger had overcome Mourinho for the first time in last month’s Community Shield, but here found himself in the familiar position of having been eclipsed by his Portuguese nemesis.
His side has not beaten Chelsea in the league since October 2011 and following the mid-week defeat at Dinamo Zagreb in which Olivier Giroud was sent off, this was another partly self-inflicted setback.
As ever in this fixture, the first tremors of the contest were felt before kick-off, with Terry’s inclusion on the substitutes’ bench followed by a keenly anticipated handshake between Wenger and Mourinho.
Wenger had swerved a chance to shake his Chelsea counterpart’s hand after Arsenal’s 1-0 win in the Community Shield, but on this occasion Mourinho made himself impossible to avoid by lingering beside the tunnel.
Eyes averted, the pair performed the most perfunctory of handshakes before taking their seats.
Mourinho said Terry’s omission was “tactical” and it seemed to reflect concern over the pace of Theo Walcott, who got in behind Chelsea’s defence early on and rounded goalkeeper Asmir Begovic, only to run the ball out.
The England forward also squandered an opportunity created by Mesut Ozil’s pass by shooting straight at Begovic, but as the first half wore on, so Chelsea’s grip on it tightened.
Back at a ground he had called home for 11 years, Cech was by far the busier goalkeeper, smothering an attempt from Pedro Rodriguez, brilliantly picked out by Fabregas, and later parrying the Spain forward’s 20-yard drive.
Zouma and Pedro also shot narrowly off target before the pressure finally told with the dismissal of Gabriel.
Costa, characteristically, was the catalyst, wildly lashing out at Laurent Koscielny inside the Arsenal box and then clashing with Gabriel, which saw both players booked.
But Costa continued to goad Gabriel as the players walked down the pitch and when the centre-back reacted with a sly kick, referee Mike Dean brandished the red card.
Arsenal lost Francis Coquelin at half-time, the midfielder being replaced by Chambers after hurting his knee during the first half, and eight minutes into the second half it lost parity in the match as well.
Fabregas floated a left-of-centre free-kick towards the far post and Zouma stole behind Koscielny and Nacho Monreal to plant a header past Cech for his first Premier League goal.
The disappointing Alexis Sanchez spurned a presentable chance at the other end, scuffing a volley into the ground and over the bar, while Walcott curled wide.
But Arsenal’s chances vanished 12 minutes from time when Cazorla caught Fabregas on the ankle and joined Gabriel in the changing room.
The results: Chelsea 2 (Zouma 53, Hazard 90) bt Arsenal 0; Aston Villa 0 lost to West Bromwich 1 (Berahino 39); Bournemouth 2 (Wilson 4, Ritchie 9) bt Sunderland 0; Newcastle 1 (Janmaat 62) lost to Watford 2 (Ighalo 10, 28); Stoke 2 (Bojan 13, Walters 20) drew with Leicester 2 (Mahrez 51-pen, Vardy 69); Swansea 0 drew with Everton 0.