The unmanned aerial vehicle targeted a militant hideout and also destroyed some of their vehicles in the restive Khyber tribal district, the Dawn news reported.
The US drones fired three missiles on the compound, it said.
Media persons and journalists have no access to the area attacked and the death-toll could not be independently verified.
The last drone attack occurred in the last week of December, 2013, killing three suspected insurgents.
Reports in the US media have suggested the drone strikes had been temporarily halted to allow the Pakistani government a chance to hold talks with the Taliban aimed at ending their seven-year insurgency.